Key Publications

Most recent publications

click here for a list of all publications

  1. Chen, X., S. D’Arcy, C. A. Radebaugh, D. D. Krzizike, H. A. Giebler, L. Huang, J. K. Nyborg, K. Luger and L. A. Stargell (2016). “The histone chaperone Nap1 is a major regulator of histone H2A-H2B dynamics at the inducible GAL locus.” Mol Cell Biol. in press
  2. White, A.E., Hieb, A.R. and Luger, K. (2016) A quantitative investigation of linker histone interactions with nucleosomes and chromatin. Scientific Reports, 6, 19122.
  3. Klein, B.J., Muthurajan, U.M., Lalonde, M.E., Gibson, M.D., Andrews, F.H., Hepler, M., Machida, S., Yan, K., Kurumizaka, H., Poirier, M.G. et al. (2015) Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation. Nucleic acids research.
  4. Chatterjee, N., North, J.A., Dechassa, M.L., Manohar, M., Prasad, R., Luger, K., Ottesen, J.J., Poirier, M.G. and Bartholomew, B. (2015) Histone Acetylation near the Nucleosome Dyad Axis Enhances Nucleosome Disassembly by RSC and SWI/SNF. Mol Cell Biol, 35, 4083-4092.
  5. Brehove, M., Wang, T., North, J., Luo, Y., Dreher, S.J., Shimko, J.C., Ottesen, J.J., Luger, K. and Poirier, M.G. (2015) Histone core phosphorylation regulates DNA accessibility. J Biol Chem, 290, 22612-22621.
  6. Yelagandula, R., Stroud, H., Holec, S., Zhou, K., Feng, S., Zhong, X., Muthurajan, U.M., Nie, X., Kawashima, T., Groth, M. et al. (2014) The Histone Variant H2A.W Defines Heterochromatin and Promotes Chromatin Condensation in Arabidopsis. Cell, 158, 98-109.
  7. Muthurajan, U.M., Hepler, M.R., Hieb, A.R., Clark, N.J., Kramer, M., Yao, T. and Luger, K. (2014) Automodification switches PARP-1 function from chromatin architectural protein to histone chaperone. Proc Natl Acad Sci U S A, 111, 12752-12757.
  8. Groocock, L.M., Nie, M., Prudden, J., Moiani, D., Wang, T., Cheltsov, A., Rambo, R.P., Arvai, A.S., Hitomi, C., Tainer, J.A. et al. (2014) RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response. EMBO Rep, 15, 601-608.
  9. Dechassa, M.L., Wyns, K. and Luger, K. (2014) Scm3 deposits a (Cse4-H4)2 tetramer onto DNA through a Cse4-H4 dimer intermediate. Nucleic acids research, 42, 5532-5542.
  10. Chodaparambil, J.V., Pate, K.T., Hepler, M.R., Tsai, B.P., Muthurajan, U.M., Luger, K., Waterman, M.L. and Weis, W.I. (2014) Molecular functions of the TLE tetramerization domain in Wnt target gene repression. The EMBO journal, 33, 719-731.
  11. Chen, C.C., Dechassa, M.L., Bettini, E., Ledoux, M.B., Belisario, C., Heun, P., Luger, K. and Mellone, B.G. (2014) CAL1 is the Drosophila CENP-A assembly factor. J Cell Biol, 204, 313-329.
  12. D’Arcy, S., Martin, K.W., Panchenko, T., Chen, X., Bergeron, S., Stargell, L.A., Black, B.E. and Luger, K. (2013) Chaperone Nap1 Shields Histone Surfaces Used in a Nucleosome and Can Put H2A-H2B in an Unconventional Tetrameric Form. Mol Cell, 51, 662-677
  13. Winkler, D.D., Zhou, H., Dar, M.A., Zhang, Z. and Luger, K. (2012) Yeast CAF-1 assembles histone (H3-H4)2 tetramers prior to DNA deposition. Nucleic acids research, 40, 10139-10149.
  14. Hieb, A.R., D’Arcy, S., Kramer, M.A., White, A.E. and Luger, K. (2012) Fluorescence strategies for high-throughput quantification of protein interactions. Nucleic acids research, 40, e33

Methods

  1. Zhao, H., Ghirlando, R., Alfonso, C., Arisaka, F., Attali, I., Bain, D.L., Bakhtina, M.M., Becker, D.F., Bedwell, G.J., Bekdemir, A. et al. (2015) A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation. PLoS One, 10, e0126420.
  2. Winkler, D.D., Luger, K. and Hieb, A.R. (2012) Quantifying Chromatin-Associated Interactions: The HI-FI System. Methods Enzymol, 512, 243-274.
  3. Andrews, A.J. and Luger, K. (2011) A coupled equilibrium approach to study nucleosome thermodynamics. Methods Enzymol, 488, 265-285.
  4. Subramanian, V., Williams, R.M., Boger, D.L. and Luger, K. (2010) Methods to characterize the effect of DNA-modifying compounds on nucleosomal DNA. Methods Mol Biol, 613, 173-192.
  5. Dyer, P.N., Edayathumangalam, R.S., White, C.L., Bao, Y., Chakravarthy, S., Muthurajan, U.M. and Luger, K. (2004) Reconstitution of nucleosome core particles from recombinant histones and DNA. Methods Enzymol, 375, 23-44.
  6. Luger, K., Rechsteiner, T.J. and Richmond, T.J. (1999) Expression and purification of recombinant histones and nucleosome reconstitution. Methods Mol Biol, 119, 1-16.
  7. Luger, K., Rechsteiner, T.J. and Richmond, T.J. (1999) Preparation of nucleosome core particle from recombinant histones. Methods Enzymol, 304, 3-19.

Selected Reviews

  1. Mattiroli, F., D’Arcy, S. and Luger, K. (2015) The right place at the right time: chaperoning core histone variants. EMBO Rep, 16, 1454-1466.
  2. Kalashnikova, A.A., Porter-Goff, M.E., Muthurajan, U.M., Luger, K. and Hansen, J.C. (2013) The role of the nucleosome acidic patch in modulating higher order chromatin structure. J R Soc Interface, 10, 20121022.
  3. Earnshaw, W.C., Allshire, R.C., Black, B.E., Bloom, K., Brinkley, B.R., Brown, W., Cheeseman, I.M., Choo, K.H., Copenhaver, G.P., Deluca, J.G. et al. (2013) Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res, 21, 101-106.
  4. Luger, K., Dechassa, M.L. and Tremethick, D.J. (2012) New insights into nucleosome and chromatin structure: an ordered state or a disordered affair? Nat Rev Mol Cell Biol, 13, 436-447.
  5. Dechassa, M.L. and Luger, K. (2011) In Rippe, K. (ed.), In Genome organization and function in the cell nucleus. Wiley-VCH, Weinheim, Vol. in press.
  6. D’Arcy, S. and Luger, K. (2011) Understanding histone acetyltransferase Rtt109 structure and function: how many chaperones does it take? Current opinion in structural biology, 21, 728-734.
  7. Andrews, A.J. and Luger, K. (2011) Nucleosome structure(s) and stability: variations on a theme. Annu Rev Biophys, 40, 99-117.
  8. Hansen, J.C., Nyborg, J.K., Luger, K. and Stargell, L.A. (2010) Histone chaperones, histone acetylation, and the fluidity of the chromogenome. J Cell Physiol, 224, 289-299.
  9. Dechassa, M.L., D’Arcy, S. and Luger, K. (2009) A positive spin on the centromere. Cell, 138, 22-24.
  10. Andrews, A.J. and Luger, K. (2009) Histone Modifications: Chemistry and Structural Consequences. Wiley Encyclopedia of Chemical Biology, 1, 275-284.
  11. Park, Y.J. and Luger, K. (2008) Histone chaperones in nucleosome eviction and histone exchange. Current opinion in structural biology, 18, 282-289.
  12. Park, Y.J. and Luger, K. (2006) Structure and function of nucleosome assembly proteins. Biochem Cell Biol, 84, 549-558.
  13. Luger, K. (2006) Dynamic nucleosomes. Chromosome Res, 14, 5-16.
  14. Chodaparambil, J.V., Edayathumangalam, R.S., Bao, Y., Park, Y.J. and Luger, K. (2006) Nucleosome structure and function. Ernst Schering Res Found Workshop, 29-46.
  15. Barbera, A.J., Chodaparambil, J.V., Kelley-Clarke, B., Luger, K. and Kaye, K.M. (2006) Kaposi’s sarcoma-associated herpesvirus LANA hitches a ride on the chromosome. Cell Cycle, 5, 1048-1052.
  16. Luger, K. and Hansen, J.C. (2005) Nucleosome and chromatin fiber dynamics. Current opinion in structural biology, 15, 188-196.
  17. Luger, K. (2003) Structure and dynamic behavior of nucleosomes. Curr Opin Genet Dev, 13, 127-135.
  18. Akey, C.W. and Luger, K. (2003) Histone chaperones and nucleosome assembly. Current opinion in structural biology, 13, 6-14.
  19. Luger, K. (2002) The tail does not always wag the dog. Nat Genet, 16, 16.
  20. Luger, K. (2000) Nucleosomes: Structure and Function. Encyclopedia of Life Sciences, els.net.
  21. Luger, K. and Richmond, T.J. (1998) The histone tails of the nucleosome. Curr Opin Genet Dev, 8, 140-146.
  22. Luger, K. and Richmond, T.J. (1998) DNA binding within the nucleosome core. Current opinion in structural biology, 8, 33-40.